Breast tumor microenvironment: Proteomics highlights the treatments targeting secretome

Shui Tein Chen, Tai Long Pan, Hsueh Fen Juan, Tai Yuan Chen, Yih Shyan Lin, Chun Ming Huang

Research output: Contribution to journalArticlepeer-review

54 Scopus citations

Abstract

Tumor secreted substances (secretome), including extracellular matrix (ECM) components, act as mediators of tumor-host communication in the breast tumor microenvironment. Proteomic analysis has emphasized the value of the secretome as a source of prospective markers and drug targets for the treatment of breast cancers. Utilizing bioinformatics, our recent studies revealed global changes in protein expression after the activation of ECM-,mediated signaling in breast cancer cells. A newly designed technique integrating a capillary ultrafiltration (CUF) probe with mass spectrometry was demonstrated to dynamically sample and identify in vivo and pure secretome from the tumor microenvironment. Such in vivo profiling of breast cancer secretomes may facilitate the development of novel drugs specifically targeting secretome.

Original languageEnglish
Pages (from-to)1379-1387
Number of pages9
JournalJournal of Proteome Research
Volume7
Issue number4
DOIs
StatePublished - Apr 2008

Keywords

  • Breast cancer
  • Extracellular matrix
  • Secretome
  • Tumor microenvironment

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