Bonding of thermoplastic polymer microfluidics

Chia Wen Tsao, Don L. DeVoe

Research output: Contribution to journalReview articlepeer-review

488 Scopus citations


Thermoplastics are highly attractive substrate materials for microfluidic systems, with important benefits in the development of low cost disposable devices for a host of bioanalytical applications. While significant research activity has been directed towards the formation of microfluidic components in a wide range of thermoplastics, sealing of these components is required for the formation of enclosed microchannels and other microfluidic elements, and thus bonding remains a critical step in any thermoplastic microfabrication process. Unlike silicon and glass, the diverse material properties of thermoplastics opens the door to an extensive array of substrate bonding options, together with a set of unique challenges which must be addressed to achieve optimal sealing results. In this paper we review the range of techniques developed for sealing thermoplastic microfluidics and discuss a number of practical issues surrounding these various bonding methods.

Original languageEnglish
Pages (from-to)1-16
Number of pages16
JournalMicrofluidics and Nanofluidics
Issue number1
StatePublished - 2009


  • Adhesive bonding
  • Solvent bonding
  • Surface treatment and modification
  • Thermal fusion bonding
  • Welding


Dive into the research topics of 'Bonding of thermoplastic polymer microfluidics'. Together they form a unique fingerprint.

Cite this