Biodegradable hafnium-doped CaCO3 nanoparticles as a dual-modality radiosensitizer for cancer radiotherapy

Min Hua Chen, Xiang Hao Zeng, Yi Ting Shu, Hsiang Kuang Liang, Ching Yun Chen, Chun Yu Lin, Cheng An J. Lin, Jen Kun Chen

Research output: Contribution to journalArticlepeer-review

Abstract

Aim: Radiotherapy employs high-energy ionizing radiation to inflict DNA damage on cancer cells, thereby causing their demise. However, this procedure can inadvertently harm healthy tissue. Thus, this study aimed to develop biodegradable radiosensitizers that counteract these adverse effects by enhancing the radiation sensitivity of tumor cells and safeguarding normal cells. Materials & methods: A biodegradable radiosensitizer was engineered by incorporating hafnium ions (Hf) into calcium carbonate (CaCO3) nanoparticles via a chemical precipitation technique, resulting in the formation of Hf:CaCO3 nanoparticles. Results & conclusion: Our findings demonstrate that Hf:CaCO3 nanoparticles exhibit pH-dependent solubility and can augment the efficacy of radiotherapy in treating cancer cells. This research underscores the potential of Hf:CaCO3 nanoparticles as a dual-modality radiosensitizer in radiotherapy.

Original languageEnglish
Pages (from-to)1133-1144
Number of pages12
JournalNanomedicine
Volume19
Issue number13
DOIs
StatePublished - 2024

Keywords

  • bioceramics
  • cancer/oncology
  • nanomaterials
  • nanoparticles
  • therapeutics

Fingerprint

Dive into the research topics of 'Biodegradable hafnium-doped CaCO3 nanoparticles as a dual-modality radiosensitizer for cancer radiotherapy'. Together they form a unique fingerprint.

Cite this