Attentional dysfunction arises from right frontocentral and occipital network connectivity in Parkinson's disease

Isobel Timothea French; Kuo Hsuan Chang; Wei-Kuang Liang; Wen Sheng Chang; Yen Shi Lo; Yi Ru Wang; Mei Ling Cheng; Norden E. Huang; Hsiu Chuan Wu; Siew Na Lim; Chiung Mei Chen; Chi-Hung Juan

doi:10.1016/j.ynirp.2025.100241

Attentional dysfunction arises from right frontocentral and occipital network connectivity in Parkinson's disease

Isobel Timothea French, Kuo Hsuan Chang, Wei-Kuang Liang, Wen Sheng Chang, Yen Shi Lo, Yi Ru Wang, Mei Ling Cheng, Norden E. Huang, Hsiu Chuan Wu, Siew Na Lim, Chiung Mei Chen, Chi-Hung Juan

Research output: Contribution to journal › Article › peer-review

Abstract

Background: The Flanker task measures visuospatial attention and assesses the attentional network by distinguishing pathways for enhancing information at attended regions and suppressing information at unattended ones (Kopp et al., 1996). In Parkinson's disease (PD), the attentional network is impaired due to dysfunctional fronto-subcortical circuits connected to the basal ganglia, disrupting response selection and inhibition. While electroencephalography (EEG) may reveal abnormalities of these circuits in PD, dynamic brain oscillations critical for interareal communications cannot be deciphered with conventional time-frequency analyses. Objective: To utilize the novel Holo-Hilbert Spectral Analysis (HHSA) to reveal dynamic EEG features of the Flanker task in PD patients and healthy normal controls for differentiating and elucidating attentional network deficits in patients. Methods: The novel HHSA was applied to uncover nonlinear features of the Flanker task EEG and to analyse connectivity using phase-amplitude cross-frequency coupling. Results: Holo-Hilbert transform (HHT) results showed an attenuated midfrontal theta (FMθ) in the congruency effect in PD patients, consistent with past studies. HHSA showed a loss of low-frequency amplitude modulations (f_am) in the theta carrier frequency band (f_c) during the congruency effect in PD. Importantly, connectivity analyses using the Holo-Hilbert cross-frequency phase clustering (HHCFPC) revealed a loss of theta-gamma cross frequency coupling (CFC) from the right prefrontal cortex to other frontal and contralateral regions. Decrements were also shown in PD patients from right frontal cortical to occipital areas in theta-beta CFC. Conclusions: These visuospatial attention deficits of PD revealed with the advanced analytical method of the HHSA and HHCFPC may inaugurate further neurophysiological biomarkers for cognitive function evaluation in PD and related movement disorders.

Original language	English
Article number	100241
Journal	NeuroImage: Reports
Volume	5
Issue number	1
DOIs	https://doi.org/10.1016/j.ynirp.2025.100241
State	Published - Mar 2025

Keywords

Attentional network
Cross-frequency phase clustering
Electroencephalography
Parkinson's disease
Spectral analysis

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10.1016/j.ynirp.2025.100241

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@article{92d5c08a24354f4cb38874945ce1d888,

title = "Attentional dysfunction arises from right frontocentral and occipital network connectivity in Parkinson's disease",

abstract = "Background: The Flanker task measures visuospatial attention and assesses the attentional network by distinguishing pathways for enhancing information at attended regions and suppressing information at unattended ones (Kopp et al., 1996). In Parkinson's disease (PD), the attentional network is impaired due to dysfunctional fronto-subcortical circuits connected to the basal ganglia, disrupting response selection and inhibition. While electroencephalography (EEG) may reveal abnormalities of these circuits in PD, dynamic brain oscillations critical for interareal communications cannot be deciphered with conventional time-frequency analyses. Objective: To utilize the novel Holo-Hilbert Spectral Analysis (HHSA) to reveal dynamic EEG features of the Flanker task in PD patients and healthy normal controls for differentiating and elucidating attentional network deficits in patients. Methods: The novel HHSA was applied to uncover nonlinear features of the Flanker task EEG and to analyse connectivity using phase-amplitude cross-frequency coupling. Results: Holo-Hilbert transform (HHT) results showed an attenuated midfrontal theta (FMθ) in the congruency effect in PD patients, consistent with past studies. HHSA showed a loss of low-frequency amplitude modulations (fam) in the theta carrier frequency band (fc) during the congruency effect in PD. Importantly, connectivity analyses using the Holo-Hilbert cross-frequency phase clustering (HHCFPC) revealed a loss of theta-gamma cross frequency coupling (CFC) from the right prefrontal cortex to other frontal and contralateral regions. Decrements were also shown in PD patients from right frontal cortical to occipital areas in theta-beta CFC. Conclusions: These visuospatial attention deficits of PD revealed with the advanced analytical method of the HHSA and HHCFPC may inaugurate further neurophysiological biomarkers for cognitive function evaluation in PD and related movement disorders.",

keywords = "Attentional network, Cross-frequency phase clustering, Electroencephalography, Parkinson's disease, Spectral analysis",

author = "French, {Isobel Timothea} and Chang, {Kuo Hsuan} and Wei-Kuang Liang and Chang, {Wen Sheng} and Lo, {Yen Shi} and Wang, {Yi Ru} and Cheng, {Mei Ling} and Huang, {Norden E.} and Wu, {Hsiu Chuan} and Lim, {Siew Na} and Chen, {Chiung Mei} and Chi-Hung Juan",

note = "Publisher Copyright: {\textcopyright} 2025 The Authors",

year = "2025",

month = mar,

doi = "10.1016/j.ynirp.2025.100241",

language = "???core.languages.en_GB???",

volume = "5",

journal = "NeuroImage: Reports",

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TY - JOUR

T1 - Attentional dysfunction arises from right frontocentral and occipital network connectivity in Parkinson's disease

AU - French, Isobel Timothea

AU - Chang, Kuo Hsuan

AU - Liang, Wei-Kuang

AU - Chang, Wen Sheng

AU - Lo, Yen Shi

AU - Wang, Yi Ru

AU - Cheng, Mei Ling

AU - Huang, Norden E.

AU - Wu, Hsiu Chuan

AU - Lim, Siew Na

AU - Chen, Chiung Mei

AU - Juan, Chi-Hung

PY - 2025/3

Y1 - 2025/3

N2 - Background: The Flanker task measures visuospatial attention and assesses the attentional network by distinguishing pathways for enhancing information at attended regions and suppressing information at unattended ones (Kopp et al., 1996). In Parkinson's disease (PD), the attentional network is impaired due to dysfunctional fronto-subcortical circuits connected to the basal ganglia, disrupting response selection and inhibition. While electroencephalography (EEG) may reveal abnormalities of these circuits in PD, dynamic brain oscillations critical for interareal communications cannot be deciphered with conventional time-frequency analyses. Objective: To utilize the novel Holo-Hilbert Spectral Analysis (HHSA) to reveal dynamic EEG features of the Flanker task in PD patients and healthy normal controls for differentiating and elucidating attentional network deficits in patients. Methods: The novel HHSA was applied to uncover nonlinear features of the Flanker task EEG and to analyse connectivity using phase-amplitude cross-frequency coupling. Results: Holo-Hilbert transform (HHT) results showed an attenuated midfrontal theta (FMθ) in the congruency effect in PD patients, consistent with past studies. HHSA showed a loss of low-frequency amplitude modulations (fam) in the theta carrier frequency band (fc) during the congruency effect in PD. Importantly, connectivity analyses using the Holo-Hilbert cross-frequency phase clustering (HHCFPC) revealed a loss of theta-gamma cross frequency coupling (CFC) from the right prefrontal cortex to other frontal and contralateral regions. Decrements were also shown in PD patients from right frontal cortical to occipital areas in theta-beta CFC. Conclusions: These visuospatial attention deficits of PD revealed with the advanced analytical method of the HHSA and HHCFPC may inaugurate further neurophysiological biomarkers for cognitive function evaluation in PD and related movement disorders.

AB - Background: The Flanker task measures visuospatial attention and assesses the attentional network by distinguishing pathways for enhancing information at attended regions and suppressing information at unattended ones (Kopp et al., 1996). In Parkinson's disease (PD), the attentional network is impaired due to dysfunctional fronto-subcortical circuits connected to the basal ganglia, disrupting response selection and inhibition. While electroencephalography (EEG) may reveal abnormalities of these circuits in PD, dynamic brain oscillations critical for interareal communications cannot be deciphered with conventional time-frequency analyses. Objective: To utilize the novel Holo-Hilbert Spectral Analysis (HHSA) to reveal dynamic EEG features of the Flanker task in PD patients and healthy normal controls for differentiating and elucidating attentional network deficits in patients. Methods: The novel HHSA was applied to uncover nonlinear features of the Flanker task EEG and to analyse connectivity using phase-amplitude cross-frequency coupling. Results: Holo-Hilbert transform (HHT) results showed an attenuated midfrontal theta (FMθ) in the congruency effect in PD patients, consistent with past studies. HHSA showed a loss of low-frequency amplitude modulations (fam) in the theta carrier frequency band (fc) during the congruency effect in PD. Importantly, connectivity analyses using the Holo-Hilbert cross-frequency phase clustering (HHCFPC) revealed a loss of theta-gamma cross frequency coupling (CFC) from the right prefrontal cortex to other frontal and contralateral regions. Decrements were also shown in PD patients from right frontal cortical to occipital areas in theta-beta CFC. Conclusions: These visuospatial attention deficits of PD revealed with the advanced analytical method of the HHSA and HHCFPC may inaugurate further neurophysiological biomarkers for cognitive function evaluation in PD and related movement disorders.

KW - Attentional network

KW - Cross-frequency phase clustering

KW - Electroencephalography

KW - Parkinson's disease

KW - Spectral analysis

UR - http://www.scopus.com/inward/record.url?scp=85217500780&partnerID=8YFLogxK

U2 - 10.1016/j.ynirp.2025.100241

DO - 10.1016/j.ynirp.2025.100241

M3 - 期刊論文

AN - SCOPUS:85217500780

SN - 2666-9560

VL - 5

JO - NeuroImage: Reports

JF - NeuroImage: Reports

IS - 1

M1 - 100241

ER -

Attentional dysfunction arises from right frontocentral and occipital network connectivity in Parkinson's disease

Abstract

Keywords

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