ATP-Dependent Dynamic Protein Aggregation Regulates Bacterial Dormancy Depth Critical for Antibiotic Tolerance

Yingying Pu; Yingxing Li; Xin Jin; Tian Tian; Qi Ma; Ziyi Zhao; Ssu yuan Lin; Zhanghua Chen; Binghui Li; Guang Yao; Mark C. Leake; Chien Jung Lo; Fan Bai

doi:10.1016/j.molcel.2018.10.022

ATP-Dependent Dynamic Protein Aggregation Regulates Bacterial Dormancy Depth Critical for Antibiotic Tolerance

Yingying Pu, Yingxing Li, Xin Jin, Tian Tian, Qi Ma, Ziyi Zhao, Ssu yuan Lin, Zhanghua Chen, Binghui Li, Guang Yao, Mark C. Leake, Chien Jung Lo, Fan Bai

Department of Physics

Research output: Contribution to journal › Article › peer-review

111 Scopus citations

Abstract

In this work, Pu et al. introduced a concept of “dormancy depth” that provides a unifying framework for understanding both persisters and viable but non-culturable cells. Subsequent mechanistic investigations revealed how ATP-dependent dynamic protein aggregation regulates cellular dormancy and resuscitation, the fine control of which facilitates bacterial drug tolerance.

Original language	English
Pages (from-to)	143-156.e4
Journal	Molecular Cell
Volume	73
Issue number	1
DOIs	https://doi.org/10.1016/j.molcel.2018.10.022
State	Published - 3 Jan 2019

Keywords

ATP
DnaK-ClpB complex
bacterial antibiotic tolerance
cell resuscitation
dormancy depth
persisters
protein aggregates
viable but non-culturable cells

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10.1016/j.molcel.2018.10.022

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title = "ATP-Dependent Dynamic Protein Aggregation Regulates Bacterial Dormancy Depth Critical for Antibiotic Tolerance",

abstract = "In this work, Pu et al. introduced a concept of “dormancy depth” that provides a unifying framework for understanding both persisters and viable but non-culturable cells. Subsequent mechanistic investigations revealed how ATP-dependent dynamic protein aggregation regulates cellular dormancy and resuscitation, the fine control of which facilitates bacterial drug tolerance.",

keywords = "ATP, DnaK-ClpB complex, bacterial antibiotic tolerance, cell resuscitation, dormancy depth, persisters, protein aggregates, viable but non-culturable cells",

author = "Yingying Pu and Yingxing Li and Xin Jin and Tian Tian and Qi Ma and Ziyi Zhao and Lin, {Ssu yuan} and Zhanghua Chen and Binghui Li and Guang Yao and Leake, {Mark C.} and Lo, {Chien Jung} and Fan Bai",

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ATP-Dependent Dynamic Protein Aggregation Regulates Bacterial Dormancy Depth Critical for Antibiotic Tolerance. / Pu, Yingying; Li, Yingxing; Jin, Xin; Tian, Tian; Ma, Qi; Zhao, Ziyi; Lin, Ssu yuan; Chen, Zhanghua; Li, Binghui; Yao, Guang; Leake, Mark C.; Lo, Chien Jung; Bai, Fan.

In: Molecular Cell, Vol. 73, No. 1, 03.01.2019, p. 143-156.e4.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - ATP-Dependent Dynamic Protein Aggregation Regulates Bacterial Dormancy Depth Critical for Antibiotic Tolerance

AU - Pu, Yingying

AU - Li, Yingxing

AU - Jin, Xin

AU - Tian, Tian

AU - Ma, Qi

AU - Zhao, Ziyi

AU - Lin, Ssu yuan

AU - Chen, Zhanghua

AU - Li, Binghui

AU - Yao, Guang

AU - Leake, Mark C.

AU - Lo, Chien Jung

AU - Bai, Fan

PY - 2019/1/3

Y1 - 2019/1/3

N2 - In this work, Pu et al. introduced a concept of “dormancy depth” that provides a unifying framework for understanding both persisters and viable but non-culturable cells. Subsequent mechanistic investigations revealed how ATP-dependent dynamic protein aggregation regulates cellular dormancy and resuscitation, the fine control of which facilitates bacterial drug tolerance.

AB - In this work, Pu et al. introduced a concept of “dormancy depth” that provides a unifying framework for understanding both persisters and viable but non-culturable cells. Subsequent mechanistic investigations revealed how ATP-dependent dynamic protein aggregation regulates cellular dormancy and resuscitation, the fine control of which facilitates bacterial drug tolerance.

KW - ATP

KW - DnaK-ClpB complex

KW - bacterial antibiotic tolerance

KW - cell resuscitation

KW - dormancy depth

KW - persisters

KW - protein aggregates

KW - viable but non-culturable cells

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U2 - 10.1016/j.molcel.2018.10.022

DO - 10.1016/j.molcel.2018.10.022

M3 - 期刊論文

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AN - SCOPUS:85059498929

VL - 73

SP - 143-156.e4

JO - Molecular Cell

JF - Molecular Cell

SN - 1097-2765

IS - 1

ER -

ATP-Dependent Dynamic Protein Aggregation Regulates Bacterial Dormancy Depth Critical for Antibiotic Tolerance

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Keywords

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