Assessment of autonomic dysfunction in patients with type 2 diabetes using reactive hyperemia

Hsien Tsai Wu; Po Chun Hsu; Cheuk Kwan Sun; Hou Jun Wang; Cyuan Cin Liu; Hong Ruei Chen; An Bang Liu; Chieh Ju Tang; Men Tzung Lo

doi:10.1016/j.jtbi.2013.03.022

Assessment of autonomic dysfunction in patients with type 2 diabetes using reactive hyperemia

Hsien Tsai Wu, Po Chun Hsu, Cheuk Kwan Sun, Hou Jun Wang, Cyuan Cin Liu, Hong Ruei Chen, An Bang Liu, Chieh Ju Tang, Men Tzung Lo

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

It is known that aging and type 2 diabetes mellitus contribute to atherosclerosis and autonomic dysfunction. By using the air pressure sensing system (APSS), peak-peak intervals (PPIs) of wrist arterial waveforms from baseline and reactive hyperemia (RH) were obtained. Through frequency domain analysis of heart rate variability (HRV) and nonlinear Poincaré method, the HRV of healthy young individuals (Group 1, n=25), healthy upper middle-aged individuals (Group 2, n=22), and patients with type 2 diabetes (Group 3, n=28) were assessed. By using the standard deviation (SD) of the instantaneous PPI variability (SD1)/the SD of the long PPI variability (SD2) ratio (SSR), PPIs of the same individuals before and after RH induction were compared. Reduced SSR_1-10 was noted only in patients with diabetes. Moreover, a significient correlation between SSR_1-10 and endothelial function was observed in all subjects (r=0.290, p=0.033) after RH. However, no correlation with low-frequency to high-frequency power ratio (LHR) was noted before and after RH. In conclusion, according to our results, campared to the baseline, there were more significant changes of SSR_1-10 after RH in patients with diabetes; and, a significient correlation between SSR_1-10 and endothelial function at the moment of RH was noted.

Original language	English
Pages (from-to)	9-17
Number of pages	9
Journal	Journal of Theoretical Biology
Volume	330
DOIs	https://doi.org/10.1016/j.jtbi.2013.03.022
State	Published - 7 Aug 2013

Keywords

Autonomic dysfunction
Poincaré method
Pulse rate variability
SD1/SD2 ratio (SSR)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jtbi.2013.03.022

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@article{eab0fe6e62824ff9808da45701c842da,

title = "Assessment of autonomic dysfunction in patients with type 2 diabetes using reactive hyperemia",

abstract = "It is known that aging and type 2 diabetes mellitus contribute to atherosclerosis and autonomic dysfunction. By using the air pressure sensing system (APSS), peak-peak intervals (PPIs) of wrist arterial waveforms from baseline and reactive hyperemia (RH) were obtained. Through frequency domain analysis of heart rate variability (HRV) and nonlinear Poincar{\'e} method, the HRV of healthy young individuals (Group 1, n=25), healthy upper middle-aged individuals (Group 2, n=22), and patients with type 2 diabetes (Group 3, n=28) were assessed. By using the standard deviation (SD) of the instantaneous PPI variability (SD1)/the SD of the long PPI variability (SD2) ratio (SSR), PPIs of the same individuals before and after RH induction were compared. Reduced SSR1-10 was noted only in patients with diabetes. Moreover, a significient correlation between SSR1-10 and endothelial function was observed in all subjects (r=0.290, p=0.033) after RH. However, no correlation with low-frequency to high-frequency power ratio (LHR) was noted before and after RH. In conclusion, according to our results, campared to the baseline, there were more significant changes of SSR1-10 after RH in patients with diabetes; and, a significient correlation between SSR1-10 and endothelial function at the moment of RH was noted.",

keywords = "Autonomic dysfunction, Poincar{\'e} method, Pulse rate variability, SD1/SD2 ratio (SSR)",

author = "Wu, {Hsien Tsai} and Hsu, {Po Chun} and Sun, {Cheuk Kwan} and Wang, {Hou Jun} and Liu, {Cyuan Cin} and Chen, {Hong Ruei} and Liu, {An Bang} and Tang, {Chieh Ju} and Lo, {Men Tzung}",

note = "Funding Information: The authors would like to thank the anonymous Reviewers for their insightful comments and suggestions which have significantly contributed to the improvement of this work. The authors also like to thank Miss S. M. Wen, who worked as Acting Head Nurse in the Outpatient Department of Hualien Hospital for clinical Support, the volunteers involved in this study for allowing us to collect and analysis their data. The authors are grateful for the support of Texas Instruments, Taiwan , in sponsoring the low power instrumentation amplifiers and ADC tools. M-T Lo was supported by NSC (Taiwan, ROC) , Grant No 100-2221-E-008-008-MY2 , joint foundation of CGH and NCU , Grant No CNJRF-101CGH-NCU-A4 , VGHUST102-G1-2-3 and NSC support for the Center for Dynamical Biomarkers and Translational Medicine, National Central University, Taiwan ( NSC 101-2911-I-008-001 ). H-T Wu was supported by NSC , Grant No 100-2221-E-259-030-MY2 , NSC 101-2221-E-259-012 . ",

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doi = "10.1016/j.jtbi.2013.03.022",

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volume = "330",

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T1 - Assessment of autonomic dysfunction in patients with type 2 diabetes using reactive hyperemia

AU - Wu, Hsien Tsai

AU - Hsu, Po Chun

AU - Sun, Cheuk Kwan

AU - Wang, Hou Jun

AU - Liu, Cyuan Cin

AU - Chen, Hong Ruei

AU - Liu, An Bang

AU - Tang, Chieh Ju

AU - Lo, Men Tzung

N1 - Funding Information: The authors would like to thank the anonymous Reviewers for their insightful comments and suggestions which have significantly contributed to the improvement of this work. The authors also like to thank Miss S. M. Wen, who worked as Acting Head Nurse in the Outpatient Department of Hualien Hospital for clinical Support, the volunteers involved in this study for allowing us to collect and analysis their data. The authors are grateful for the support of Texas Instruments, Taiwan , in sponsoring the low power instrumentation amplifiers and ADC tools. M-T Lo was supported by NSC (Taiwan, ROC) , Grant No 100-2221-E-008-008-MY2 , joint foundation of CGH and NCU , Grant No CNJRF-101CGH-NCU-A4 , VGHUST102-G1-2-3 and NSC support for the Center for Dynamical Biomarkers and Translational Medicine, National Central University, Taiwan ( NSC 101-2911-I-008-001 ). H-T Wu was supported by NSC , Grant No 100-2221-E-259-030-MY2 , NSC 101-2221-E-259-012 .

PY - 2013/8/7

Y1 - 2013/8/7

N2 - It is known that aging and type 2 diabetes mellitus contribute to atherosclerosis and autonomic dysfunction. By using the air pressure sensing system (APSS), peak-peak intervals (PPIs) of wrist arterial waveforms from baseline and reactive hyperemia (RH) were obtained. Through frequency domain analysis of heart rate variability (HRV) and nonlinear Poincaré method, the HRV of healthy young individuals (Group 1, n=25), healthy upper middle-aged individuals (Group 2, n=22), and patients with type 2 diabetes (Group 3, n=28) were assessed. By using the standard deviation (SD) of the instantaneous PPI variability (SD1)/the SD of the long PPI variability (SD2) ratio (SSR), PPIs of the same individuals before and after RH induction were compared. Reduced SSR1-10 was noted only in patients with diabetes. Moreover, a significient correlation between SSR1-10 and endothelial function was observed in all subjects (r=0.290, p=0.033) after RH. However, no correlation with low-frequency to high-frequency power ratio (LHR) was noted before and after RH. In conclusion, according to our results, campared to the baseline, there were more significant changes of SSR1-10 after RH in patients with diabetes; and, a significient correlation between SSR1-10 and endothelial function at the moment of RH was noted.

AB - It is known that aging and type 2 diabetes mellitus contribute to atherosclerosis and autonomic dysfunction. By using the air pressure sensing system (APSS), peak-peak intervals (PPIs) of wrist arterial waveforms from baseline and reactive hyperemia (RH) were obtained. Through frequency domain analysis of heart rate variability (HRV) and nonlinear Poincaré method, the HRV of healthy young individuals (Group 1, n=25), healthy upper middle-aged individuals (Group 2, n=22), and patients with type 2 diabetes (Group 3, n=28) were assessed. By using the standard deviation (SD) of the instantaneous PPI variability (SD1)/the SD of the long PPI variability (SD2) ratio (SSR), PPIs of the same individuals before and after RH induction were compared. Reduced SSR1-10 was noted only in patients with diabetes. Moreover, a significient correlation between SSR1-10 and endothelial function was observed in all subjects (r=0.290, p=0.033) after RH. However, no correlation with low-frequency to high-frequency power ratio (LHR) was noted before and after RH. In conclusion, according to our results, campared to the baseline, there were more significant changes of SSR1-10 after RH in patients with diabetes; and, a significient correlation between SSR1-10 and endothelial function at the moment of RH was noted.

KW - Autonomic dysfunction

KW - Poincaré method

KW - Pulse rate variability

KW - SD1/SD2 ratio (SSR)

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U2 - 10.1016/j.jtbi.2013.03.022

DO - 10.1016/j.jtbi.2013.03.022

M3 - 期刊論文

C2 - 23583956

AN - SCOPUS:84877125546

SN - 0022-5193

VL - 330

SP - 9

EP - 17

JO - Journal of Theoretical Biology

JF - Journal of Theoretical Biology

ER -

Assessment of autonomic dysfunction in patients with type 2 diabetes using reactive hyperemia

Abstract

Keywords

UN SDGs

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