Anatomic differences between Parkinson's disease and essential tremor using ICA-based brain morphometry

Jeng Ren Duann, Ching Hung Lin, Chun Min Chen, Ming Kuei Lu, Chon Haw Tsai, Jin Chern Chiou

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

This study used independent component analysis (ICA) to decompose the surrogate image data by concatenating in space multiple subjects' anatomical images after spatial normalization and smoothing to make all images in the same space. The multiple-subject anatomical image data included three different subject/patient populations, namely the Parkinson's disease (PD) and essential tremor (ET) as well as age-matched normal control (NC) subjects. In so doing, we were to extract the independent components showing significant group differences caused by the morphometric changes due to the neurological diseases. Such an independent component-based morphometry (ICBM) applied to both the grouped gray-matter and white-matter image data could be used to successfully reveal the brain areas within the gray and white matters showing significant group differences. In gray matter, we found a majority of basal ganglia brain areas associated with NC > PD, which well represented the causes of PD reported in the literature. In addition, the ICBM also found the brain areas of right superior temporal gyrus, right angular gyrus (BA 39), right inferior temporal gyrus, and left middle temporal gyrus (BA 37) associated with NC > ET. On the other hand, a more complicated patterns were found in the white matter associated with PD > ET and ET > PD conditions.

Original languageEnglish
Title of host publication2013 6th International IEEE EMBS Conference on Neural Engineering, NER 2013
Pages573-576
Number of pages4
DOIs
StatePublished - 2013
Event2013 6th International IEEE EMBS Conference on Neural Engineering, NER 2013 - San Diego, CA, United States
Duration: 6 Nov 20138 Nov 2013

Publication series

NameInternational IEEE/EMBS Conference on Neural Engineering, NER
ISSN (Print)1948-3546
ISSN (Electronic)1948-3554

Conference

Conference2013 6th International IEEE EMBS Conference on Neural Engineering, NER 2013
Country/TerritoryUnited States
CitySan Diego, CA
Period6/11/138/11/13

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