Analysis of ultramicro biomedical samples with microfabricated chemical sensors: sample/reagent adsorption on alumina vs. pyrex substrates

Kwong Yue Hui, Richard S. Diefes, Laurie Dudik, Chung Chiun Liu, Miklos Gratzl

Research output: Contribution to journalConference articlepeer-review

Abstract

Microfabricated platinum redox sensors can be used for indication in redox diffusional microtitration of microliter size body fluid samples. The sensor can be deposited onto different substrate materials. Adsorption of reagent and/or sample on alumina ceramic substrate versus Pyrex glass substrate is compared. It is demonstrated that in a classical iodimetric redox titration system, significant adsorption occurs on alumina ceramic substrate, causing irreproducible results. Reproducibility with a 1.7% coefficient of variation (CV) is achieved using a sensor deposited on Pyrex substrate for the analysis of 20 μL sample droplets.

Original languageEnglish
Pages (from-to)824-825
Number of pages2
JournalAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume16
Issue numberpt 2
StatePublished - 1994
EventProceedings of the 16th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Part 1 (of 2) - Baltimore, MD, USA
Duration: 3 Nov 19946 Nov 1994

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