Analysis of nonylphenol polyethoxycarboxylates and their related metabolites by on-line derivatization and ion-trap gas chromatography-mass spectrometry

Wang Hsien Ding, Chung Tsen Chen

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38 Scopus citations

Abstract

This study presents a modified method to analyze nonylphenol polyethoxycarboxylates (NPEC) and their related metabolites (carboxyalkylphenol ethoxycarboxylates (CNPEC)) in water samples. The method involves extraction of samples by a graphitized carbon black (GCB) cartridge, and direct derivatization in the GC injection-port using a large-volume (10-20 μl) direct sample introduction (DSI) device with tetraalkylammonium (TAA) salts. The analytes are identified and quantitated by ion-trap GC-MS. The large-volume DSI injection-port derivatization technique provides sensitivity, fast and reproducible results for NPEC and their metabolites, to quantitation at 0.1 μg/l in 200 ml of water samples. The retention effect of TAA salts in the injection-port is not detected. In addition, the significant [M-29]+ ions and molecular ions of butylated NPEC and CNPEC residues are observed. Recovery of NP1EC in spiked water samples ranges from 90 to 108%. Moreover, relative standard deviations of replicate analyses ranges from 1 to 9%. However, unsatisfactory on-line derivatization of CNPEC residues is observed. This finding maybe owing to their lesser dissociation with the ion-pair reagent in chloroform. Copyright (C) 1999 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)113-120
Number of pages8
JournalJournal of Chromatography A
Volume862
Issue number1
DOIs
StatePublished - 5 Nov 1999

Keywords

  • Carboxyalkylphenol ethoxycarboxylates
  • Derivatization, GC
  • Nonylphenol polyethoxylates
  • Tetraalkylammonium salts

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