An expedient N-terminal attachment methodology for the solid phase peptide synthesis

W. R. Li, Tsai Lin Sung Tsai Lin, Hsiu Yang Jian Hsiu Yang

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

A general and successful N-terminal attachment methodology is described that allows the solid phase synthesis of oligopeptides from activated N-hydroxysuccinimide esters and amino acid lithium salts. The results of studies with different coupling systems for amide bond formation are presented. The oligomers were synthesized on solid support using a carbamate linker with final TFA/CH2Cl2 cleavage. This methodology was also applied for the preparation of peptide-substituted amides and esters in high purities and excellent yields.

Original languageEnglish
Pages (from-to)1608-1612
Number of pages5
JournalSynlett
Issue number11
StatePublished - 2000

Keywords

  • Amide formation
  • N-hydroxysuccinimide esters
  • N-terminal attachment
  • Peptide esters
  • Peptide-substituted amides
  • Solid-phase synthesis

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