An event-related fMRI investigation of phonological versus semantic short-term memory

Randi C. Martin, Denise Wu, Monica Freedman, Edward F. Jackson, Mary Lesch

Research output: Contribution to journalArticlepeer-review

52 Scopus citations

Abstract

Studies with normal and brain damaged subjects have indicated that there are semantic as well as phonological contributions to verbal short-term memory. An event-related functional MRI study was carried out to determine if different brain regions would be activated during the delay period in a phonological vs. a semantic retention task. A recognition probe procedure was used in which memory load and task (i.e. rhyme judgment vs. synonym judgment) were manipulated. A left inferior parietal region overlapping the supramarginal gyrus was more activated in the phonological than the semantic task. A large left inferior and mid-frontal region and another left parietal region showed a load effect that was common to the phonological and semantic tasks. No region showed significantly greater activation in the semantic than the phonological task, though there was a trend towards a more anterior localization of the frontal load effect in the semantic task compared to the phonological task.

Original languageEnglish
Pages (from-to)341-360
Number of pages20
JournalJournal of Neurolinguistics
Volume16
Issue number4-5
DOIs
StatePublished - 2003

Keywords

  • Frontal lobe
  • Functional MRI
  • Parietal lobe
  • Phonological retention
  • Semantic retention
  • Short-term memory

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