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We developed a composite wound dressing that provides multifunctional wound care. Alginate and polycaprolactone (PCL) were coelectrospun as composite fibers. Highly absorbent alginate provided a moist environment for wounds and PCL increased cell adhesion. Silver nanoparticles embedded in PCL fibers for long-term release inhibited the growth of microorganisms. In addition, plasmid DNA encoding platelet-derived growth factor-B (PDGF-B) were complexed with polyethylenimine (PEI) to form cationic nanoparticles which were then adsorbed on anionic alginate fibers through electrostatic interaction. As wound cells adhered to composite fibers, they were in situ transfected to express PDGF-B continuously. Moreover, calcium ions in alginate fibers were released into the wound site through ion exchange to accelerate hemostasis. Wound healing experiments demonstrated that PDGF-B gene-loaded composite fibers accelerated wound closure and promoted collagen formation. We expect this comprehensive study offers an ideal multifunctional solution to facilitate wound healing.
|State||Published - 1 Aug 2022|
- Composite electrospun fibers
- Platelet-derived growth factor-B
- Wound dressing
FingerprintDive into the research topics of 'Alginate/polycaprolactone composite fibers as multifunctional wound dressings'. Together they form a unique fingerprint.
- 1 Finished
The Development of Composite Fibers as Multifunctional Wound Dressings for the Treatment of Diabetic Ulcer
1/08/18 → 31/07/19