Adrenalectomy improves increased carotid intima-media thickness and arterial stiffness in patients with aldosterone producing adenoma

Yen Hung Lin, Lian Yu Lin, Aaron Chen, Xue Ming Wu, Jen Kuang Lee, Ta Chen Su, Vin Cent Wu, Shih Chieh Chueh, Wei Chou Lin, Men Tzung Lo, Pa Chun Wang, Yi Lwun Ho, Kwan Dun Wu

Research output: Contribution to journalArticlepeer-review

87 Scopus citations


Context: Primary aldosteronism (PA) is the most frequent cause of secondary hypertension, and is associated with more prominent vascular stiffness and atherosclerosis. However, the effect of adrenalectomy on reversibility of vascular damage is unclear. Objective: Our objective was to investigate the vascular changes and possibility of reversibility after adrenalectomy in PA patients. Methods: We prospectively analyzed 20 patients with aldosterone producing adenoma (APA) that received adrenalectomy from October 2006 to December 2008 and 21 patients with essential hypertension (EH) were enrolled as the control group. Carotid intima media thickness (CIMT) measurement by B-mode ultrasound of the right common carotid arteries and pulse wave velocity (PWV) measurement including brachial-ankle PWV (baPWV) and heart-ankle PWV (haPWV) were performed in both groups. The follow-up measurements were performed one-year after adrenalectomy in APA group. Results: APA patients had significantly higher diastolic blood pressure, plasma aldosterone concentration (PAC) and aldosterone-renin ratio (ARR), but lower serum potassium level and plasma renin activity (PRA) than EH patients. APA patients had significantly higher CIMT (0.64 ± 0.13 vs. 0.53 ± 0.10. mm, p= 0.006), higher baPWV (1589 ± 296 vs. 1405 ± 187. cm/s, p= 0.024) and haPWV (1095 ± 150 vs. 987 ± 114. cm/s, p= 0.013) comparing with EH patients. One-year after adrenalectomy, CIMT reduced significantly from 0.64 ± 0.13. mm to 0.59 ± 0.14. mm (p= 0.014), and baPWV and haPWV also showed significant reduction (baPWV, 1589 ± 296 to 1463 ± 188. cm/s, p= 0.035; haPWV, 1095 ± 150 to 1017 ± 109. cm/s, p= 0.019). Conclusion: APA patients have higher degree of early atherosclerosis and vascular stiffness. Adrenalectomy not only corrects the high blood pressure and biochemical parameters but also reverse adverse vascular change in APA patients.

Original languageEnglish
Pages (from-to)154-159
Number of pages6
Issue number1
StatePublished - Mar 2012


  • Adrenalectomy
  • Aldosterone producing adenoma
  • Carotid intima media thickness
  • Primary aldosteronism
  • Pulse wave velocity


Dive into the research topics of 'Adrenalectomy improves increased carotid intima-media thickness and arterial stiffness in patients with aldosterone producing adenoma'. Together they form a unique fingerprint.

Cite this