A Shared Hippocampal Network in Retrieving Science-related Semantic Memories

Hsiao Ching She, Li Yu Huang, Jeng Ren Duann

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

In responding to the calls for revisiting the role that hippocampus (HIP) plays in semantic memory retrieval, this study used functional neuroimaging-based connectivity technique to elucidate the functional brain network involved in retrieving the correct and incorrect science-related semantic memories. Unlike episodic memory retrieval, the 40 scientific concepts learned during middle and high school were selected to assess 46 science majors' semantic memory retrieval and correctness monitoring, which requires neither the support of spatial information nor events to retrieve the memory. Our results demonstrated that HIP was significantly and robustly engaged in the semantic memory retrieval of correct scientific concepts than incorrect ones. Importantly, the Granger causality analysis indicated that effective connectivity of INS→HIP and MTG→HIP was shared by the semantic memory retrieval of both correct and incorrect scientific concepts. On the other hand, the strengths of connectivity in the MTG→HIP and INS→ACC→HIP brain networks appeared more pronounced during the processing of correct scientific concepts than of incorrect ones. The shared hippocampal networks highlight the role of the HIP as a hub to coordinate the INS, ACC, and MTG, in turn, support the semantic memory retrieval of scientific concepts.

Original languageEnglish
Article number2350034
JournalInternational journal of neural systems
Volume33
Issue number8
DOIs
StatePublished - 1 Aug 2023

Keywords

  • Semantic memory retrieval
  • functional connectivity
  • hippocampus
  • scientific concepts
  • shared hippocampal network

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