TY - JOUR
T1 - A sensitivity comparison of optical biosensors based on four different surface plasmon resonance modes
AU - Chien, F. C.
AU - Chen, S. J.
N1 - Funding Information:
The current authors wish to acknowledge the financial support provided to this study by the Ministry of Education, Taiwan under Grant No. A-91-E-FA08-1-4.
PY - 2004/10/15
Y1 - 2004/10/15
N2 - Current surface plasmon resonance (SPR) modes based on the attenuated total reflection (ATR) method can broadly be categorized as: conventional SPR, long-range SPR (LRSPR), coupled plasmon-waveguide resonance (CPWR), and waveguide-coupled SPR (WCSPR). Although the features of optical biosensors are dependent upon their particular SPR mode, a common requirement for all biosensors utilized for biomolecular interaction analysis (BIA) is a high degree of sensitivity. The current paper presents a theoretical analysis and comparison of the sensitivity and resolution of these four types of SPR biosensors when employed in three of the most prevalent detection methods, namely angular interrogation, wavelength interrogation, and intensity measurement. This study develops a detailed understanding of the influences of various biosensor design parameters in order to enhance the sensitivity and detection limit capabilities of such devices.
AB - Current surface plasmon resonance (SPR) modes based on the attenuated total reflection (ATR) method can broadly be categorized as: conventional SPR, long-range SPR (LRSPR), coupled plasmon-waveguide resonance (CPWR), and waveguide-coupled SPR (WCSPR). Although the features of optical biosensors are dependent upon their particular SPR mode, a common requirement for all biosensors utilized for biomolecular interaction analysis (BIA) is a high degree of sensitivity. The current paper presents a theoretical analysis and comparison of the sensitivity and resolution of these four types of SPR biosensors when employed in three of the most prevalent detection methods, namely angular interrogation, wavelength interrogation, and intensity measurement. This study develops a detailed understanding of the influences of various biosensor design parameters in order to enhance the sensitivity and detection limit capabilities of such devices.
KW - Biomolecular interaction analysis
KW - Conventional surface plasmon resonance
KW - Coupled plasmon-waveguide resonance
KW - Long-range surface plasmon resonance
KW - Waveguide-coupled surface plasmon resonance
UR - http://www.scopus.com/inward/record.url?scp=7444250743&partnerID=8YFLogxK
U2 - 10.1016/j.bios.2004.03.014
DO - 10.1016/j.bios.2004.03.014
M3 - 期刊論文
C2 - 15494249
AN - SCOPUS:7444250743
SN - 0956-5663
VL - 20
SP - 633
EP - 642
JO - Biosensors and Bioelectronics
JF - Biosensors and Bioelectronics
IS - 3
ER -