A review of critical brain oscillations in depression and the efficacy of transcranial magnetic stimulation treatment

Yi Chun Tsai, Cheng Ta Li, Chi Hung Juan

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations

Abstract

Repetitive transcranial magnetic stimulation (rTMS) and intermittent theta burst stimulation (iTBS) have been proven effective non-invasive treatments for patients with drug-resistant major depressive disorder (MDD). However, some depressed patients do not respond to these treatments. Therefore, the investigation of reliable and valid brain oscillations as potential indices for facilitating the precision of diagnosis and treatment protocols has become a critical issue. The current review focuses on brain oscillations that, mostly based on EEG power analysis and connectivity, distinguish between MDD and controls, responders and non-responders, and potential depression severity indices, prognostic indicators, and potential biomarkers for rTMS or iTBS treatment. The possible roles of each biomarker and the potential reasons for heterogeneous results are discussed, and the directions of future studies are proposed.

Original languageEnglish
Article number1073984
JournalFrontiers in Psychiatry
Volume14
DOIs
StatePublished - 2023

Keywords

  • brain oscillations
  • EEG connectivity
  • intermittent theta burst stimulation (iTBS)
  • major depressive disorder (MDD)
  • repetitive transcranial magnetic stimulation (rTMS)

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