A peptide with a ProGln C terminus in the human saliva peptidome exerts bactericidal activity against Propionibacterium acnes

Chun Ming Huang; Justin W. Torpey; Yu Tseung Liu; Yun Ru Chen; Katherine E. Williams; Elizabeth A. Komives; Richard L. Gallo

doi:10.1128/AAC.01347-07

A peptide with a ProGln C terminus in the human saliva peptidome exerts bactericidal activity against Propionibacterium acnes

Chun Ming Huang, Justin W. Torpey, Yu Tseung Liu, Yun Ru Chen, Katherine E. Williams, Elizabeth A. Komives, Richard L. Gallo

Department of Biomedical Sciences and Engineering

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Nine proline-rich peptides ending with a proline-glutamine C terminus in a salivary peptidome were sequenced by matrix-assisted laser desorption ionization time of flight time of flight tandem mass spectrometry. A GPPPQG GRPQ peptide binds gram-positive Propionibacterium acnes and considerably inhibits bacterial growth. The peptide exhibiting innate immunity may be applied for treatment of various P. acnes-associated human diseases.

Original language	English
Pages (from-to)	1834-1836
Number of pages	3
Journal	Antimicrobial Agents and Chemotherapy
Volume	52
Issue number	5
DOIs	https://doi.org/10.1128/AAC.01347-07
State	Published - May 2008

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title = "A peptide with a ProGln C terminus in the human saliva peptidome exerts bactericidal activity against Propionibacterium acnes",

abstract = "Nine proline-rich peptides ending with a proline-glutamine C terminus in a salivary peptidome were sequenced by matrix-assisted laser desorption ionization time of flight time of flight tandem mass spectrometry. A GPPPQG GRPQ peptide binds gram-positive Propionibacterium acnes and considerably inhibits bacterial growth. The peptide exhibiting innate immunity may be applied for treatment of various P. acnes-associated human diseases.",

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AU - Huang, Chun Ming

AU - Torpey, Justin W.

AU - Liu, Yu Tseung

AU - Chen, Yun Ru

AU - Williams, Katherine E.

AU - Komives, Elizabeth A.

AU - Gallo, Richard L.

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AB - Nine proline-rich peptides ending with a proline-glutamine C terminus in a salivary peptidome were sequenced by matrix-assisted laser desorption ionization time of flight time of flight tandem mass spectrometry. A GPPPQG GRPQ peptide binds gram-positive Propionibacterium acnes and considerably inhibits bacterial growth. The peptide exhibiting innate immunity may be applied for treatment of various P. acnes-associated human diseases.

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M3 - 期刊論文

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JF - Antimicrobial Agents and Chemotherapy

IS - 5

ER -

A peptide with a ProGln C terminus in the human saliva peptidome exerts bactericidal activity against Propionibacterium acnes

Abstract

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