A microfluidic chip integrated with molecular imprinting polymers for surface plasmon resonance detection

Shih Chiang Huang, Fan Ching Chien, Jan Sheng Lin, Shean Jen Chen, Wen Janq Chen, Gwo Bin Lee

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

4 Scopus citations

Abstract

This paper reports a novel microfluidic chip integrated with molecular imprinting polymers (MIP) for surface plasmon resonance (SPR) detection of specific label-free bio-samples. The innovative microfluidic biochip is capable of transporting a specific amount of bio-samples inside multiple microchannels using micropumps/microvalves to sensing regions where multiple MIP films are locally deposited such that highly-sensitive, highly-specific bio-sensing could be achieved. With the help of SPR sensing techniques, the microfluidic biochips have the potential to be widely used for bio-sensing applications. While compared to other sensing techniques, the developed system has several advantages, including labeling-free, high sensitivity, capability of quantitative analysis of nano-scale bio-molecules in real-time fashion.

Original languageEnglish
Title of host publicationTRANSDUCERS '05 - 13th International Conference on Solid-State Sensors and Actuators and Microsystems - Digest of Technical Papers
Pages1776-1779
Number of pages4
StatePublished - 2005
Event13th International Conference on Solid-State Sensors and Actuators and Microsystems, TRANSDUCERS '05 - Seoul, Korea, Republic of
Duration: 5 Jun 20059 Jun 2005

Publication series

NameDigest of Technical Papers - International Conference on Solid State Sensors and Actuators and Microsystems, TRANSDUCERS '05
Volume2

Conference

Conference13th International Conference on Solid-State Sensors and Actuators and Microsystems, TRANSDUCERS '05
Country/TerritoryKorea, Republic of
CitySeoul
Period5/06/059/06/05

Keywords

  • Microfluidic
  • Micropumps
  • MIP
  • SPR

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