A cuprous oxide thin film non-enzymatic glucose sensor using differential pulse voltammetry and other voltammetry methods and a comparison to different thin film electrodes on the detection of glucose in an alkaline solution

Yifan Dai, Alireza Molazemhosseini, Kevin Abbasi, Chung Chiun Liu

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

A cuprous oxide (Cu2O) thin layer served as the base for a non-enzymatic glucose sensor in an alkaline medium, 0.1 NaOH solution, with a linear range of 50-200 mg/dL using differential pulse voltammetry (DPV) measurement. An X-ray photoelectron spectroscopy (XPS) study confirmed the formation of the cuprous oxide layer on the thin gold film sensor prototype. Quantitative detection of glucose in both phosphate-buffered saline (PBS) and undiluted human serum was carried out. Neither ascorbic acid nor uric acid, even at a relatively high concentration level (100 mg/dL in serum), interfered with the glucose detection, demonstrating the excellent selectivity of this non-enzymatic cuprous oxide thin layer-based glucose sensor. Chronoamperometry and single potential amperometric voltammetry were used to verify the measurements obtained by DPV, and the positive results validated that the detection of glucose in a 0.1 M NaOH alkaline medium by DPV measurement was effective. Nickel, platinum, and copper are commonly used metals for non-enzymatic glucose detection. The performance of these metal-based sensors for glucose detection using DPV were also evaluated. The cuprous oxide (Cu2O) thin layer-based sensor showed the best sensitivity for glucose detection among the sensors evaluated.

Original languageEnglish
Article number4
JournalBiosensors
Volume8
Issue number1
DOIs
StatePublished - 6 Jan 2018

Keywords

  • Alkaline solution
  • Cuprous oxide
  • Differential pulse voltammetry
  • Non-enzymatic glucose sensor

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