In this paper, the handoff procedures of 802.16e and mobile IPv6 (MIPv6) are reconstructed to achieve a better transmission performance. The concept of cross layer design is adopted to refine the existing handoff procedures specified in 802.16e MAC layer and MIPv6. There is twofold for the cross layer design in our approach. First, the handoff procedure of layer 3 can be interleaved with that of layer 2 and the process of both layers can be more coincident Second, the handoff performance is improved through the integrated design. In addition to studying the handoff latency affected by the frame duration of 802.16e and connection dropping rate caused by handoff, the proposed scheme is compared with a scheme proposed in IETF draft The simulation results show that our scheme is superior to the other scheme.