β-Oscillations Reflect Recovery of the Paretic Upper Limb in Subacute Stroke

Chih Wei Tang, Fu Jung Hsiao, Po Lei Lee, Yun An Tsai, Ya Fang Hsu, Wei Ta Chen, Yung Yang Lin, Charlotte J. Stagg, I. Hui Lee

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Background. Recovery of upper limb function post-stroke can be partly predicted by initial motor function, but the mechanisms underpinning these improvements have yet to be determined. Here, we sought to identify neural correlates of post-stroke recovery using longitudinal magnetoencephalography (MEG) assessments in subacute stroke survivors. Methods. First-ever, subcortical ischemic stroke survivors with unilateral mild to moderate hand paresis were evaluated at 3, 5, and 12 weeks after stroke using a finger-lifting task in the MEG. Cortical activity patterns in the β-band (16-30 Hz) were compared with matched healthy controls. Results. All stroke survivors (n=22; 17 males) had improvements in action research arm test (ARAT) and Fugl-Meyer upper extremity (FM-UE) scores between 3 and 12 weeks. At 3 weeks post-stroke the peak amplitudes of the movement-related ipsilesional β-band event-related desynchronization (β-ERD) and synchronization (β-ERS) in primary motor cortex (M1) were significantly lower than the healthy controls (p<0.001) and were correlated with both the FM-UE and ARAT scores (r=0.51-0.69, p<0.017). The decreased β-ERS peak amplitudes were observed both in paretic and non-paretic hand movement particularly at 3 weeks post-stroke, suggesting a generalized disinhibition status. The peak amplitudes of ipsilesional β-ERS at week 3 post-stroke correlated with the FM-UE score at 12 weeks (r=0.54, p=0.03) but no longer significant when controlling for the FM-UE score at 3 weeks post-stroke.Conclusions. Although early β-band activity does not independently predict outcome at 3 months after stroke, it mirrors functional changes, giving a potential insight into the mechanisms underpinning recovery of motor function in subacute stroke.

Original languageEnglish
Pages (from-to)450-462
Number of pages13
JournalNeurorehabilitation and Neural Repair
Volume34
Issue number5
DOIs
StatePublished - 1 May 2020

Keywords

  • event-related desynchronization
  • event-related synchronization
  • magnetoencephalography
  • motor recovery
  • stroke
  • β-oscillations

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