The role and molecular mechanism of IL-11 in seleno-compound induced cell death in colorectal cancer cells

Project Details

Description

In Taiwan, colorectal cancer is one of the greatest frequently diagnosed cancers in recent years. However, therapy strategy of colorectal cancer is mainly dependent on surgery combined with chemotherapy or radiotherapy, which is effective in early stage of colorectal cancer but poorly effective in metastasis or postoperative recurrence of colorectal cancer. Hence, it is in urgent need of discovery effective chemotherapy for colorectal cancer. Many studies have reported that ROS could mediate the colorectal carcinogenesis through gene mutations, redox related signaling pathways and redox related transcription factors. Selenium (Se) is an essential and unique element that plays a vital role in health and disease. Redox-active Se compounds have a strong selectivity toward cancer cells over normal cells. Mechanistic studies showed that selenocompound time- and dose-dependently increased intracellular ROS in various susceptible cancer cells. However, the precise molecular targets and mechanisms engaged following Se compounds treatment in various cancer models not in normal cells are still inconclusive. Therefore, it is worth to investigate whether selenocompound act as effective chemotherapy and clarify precise molecular targets and mechanisms in colorectal cancer. ROS can play an important role in inflammation by inducing the secretion of pro-or anti-inflammatory molecules regulating the different steps of cancer development 20. Inflammation promotes cancer proliferation and survival, further induces metastasis and impair responses to chemo- and radiotherapy. Meanwhile, inflammation also facilitate immune response to amplifies anti-cancer immunity. Several cytokines are involved in the interactions of autophagy with tumor inflammation, including interleukin-1(IL-1), IL-6, CXCL8/ IL8 (C-X-C motif chemokine ligand 8), and IL-10. Our preliminary data showed that Se compound (Sec) increased expressions of various immune-related genes after 24 hr treatment in HepG2 cells IL-11 was the most highly induced cytokine. We also found that the levels of IL-11 increased after Se compound treatment in human colorectal cancer WiDr cells. In this study, we will study the role of IL-11 in seleno-compound induced cell death in colorectal cancer cells.
StatusFinished
Effective start/end date1/08/2131/07/22

UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This project contributes towards the following SDG(s):

  • SDG 11 - Sustainable Cities and Communities
  • SDG 14 - Life Below Water

Keywords

  • colorectal cancer
  • molecular targets
  • cytokine

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