Peritoneal fibrosis in patients with peritoneal dialysis

Project Details


Encapsulating peritoneal sclerosis (EPS) is a fatal complication in patients on peritoneal dialysis for end- stage renal disease. However, the diagnosis of EPS is required for the experienced physician and there is currently no appropriate non-invasive biomarker to provide diagnosis and follow-up. Studies of miRNAs in blood as biomarkers were initiated since 2008 and indicated microRNAs (miRNAs) have the potential to be novel non-invasive biomarkers. Moreover, miRNA s have been demonstrated to be the main regulators of post-transcriptional gene expression. The abnormal expression of microRNAs would lead to many diseases. To utilize miRNAs to mimic or inhibit endogenous miRNA expressions may provide a powerful therapeutic strategy to interfere with key signal transduction pathways, which is applied in clinical trials currently. We investigated the expression of miRNAs from the effluent of PD patients to establish a pre-diction model to identify EPS. In this research project, we expect to expand the number, source of specimens, and further verify whether these signature-based model of EPS could be the detection biomarkers. Moreover, we will investigate the effects of new identified miRNAs on pathogenesis of EPS,and their mechanisms will be explored in greater detail.
Effective start/end date1/01/2331/12/23

UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This project contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being


  • Encapsulating peritoneal sclerosis


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