The skin is the largest organ of the human body. It mainly prevents energy loss, maintains water balance in the body and resists the invasion of foreign pathogens. Therefore, when the skin is damaged, the urging purpose of treatment is to accelerate wound healing and protect from inflammation or infection. For severe burn injury, skin grafting is required to maintain life. In this project, three-dimensional printing technology with the clinical grade CollgelⓇ bioink will be used as an ECM for supporting the HDFs ingrowth in 3D stereoscopic construction. The CollgelⓇ bioink is mixed with HDFs to form cell-laden gel for 3DP technique for uniform dermis-like tissue formation, moreover, HEKs will be seeded on the surface for producing epidermal/dermal bilayer structure in the upper layer of the cell inserts. The epidermal/dermal bilayer construct will combine with the self-designed dynamic circulating device to imitate the normal physiological micro-environment of human skin. Our research team will integrate the preliminary results and experience of last year, introduce new engineering processes for developing uniform biomimetic skin tissues in-vitro.
|Effective start/end date
|1/06/22 → 31/07/23
UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This project contributes towards the following SDG(s):
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