Results in our recent publication have revealed that the cyclophilin A is essential role for Staphylococcus epidermidis (S. epidermidis), an abundant skin commensal bacterium, to produce electricity. Blockage of clophilin A considerably lowered the electricity production of S. epidermidis. We hypothesize that lectricity mediated-electricity of S. epidermidis can mitigate uremic pruritus in patients receiving kidney ialysis. Three Specific Aims are proposed to test our hypothesis. In Specific Aim 1, we will examine the bundance of electrogenic S. epidermidis in uremic pruritus; and verify the signaling of cyclophilin-flavin mononucleotide (FMN) induced by electrogenic S. epidermidis. In Specific Aim 2, we will evaluate the influence of S. epidermidis electricity on production of free radicals a mouse model of calcium phosphate-induced pruritus; and investigate the anti-inflammatory and anti-pruritic activity of electrogenic S. epidermidis. In Specific Aim 3, we will characterize the sources of electron donors of electorgenic S. epidermidis; and detect the interaction of electrogenic S. epidermidis with other bacteria in the pruritic skin microbiome. If successful, we will validate for the first time that electrogenic bacteria promote human health by yielding therapeutic electrons to reduce the high level of free radicals and pro-inflammatory which have been implicated in the pathology of several human diseases, including cancer, inflammation and infections.
|Effective start/end date||1/08/21 → 31/01/22|
UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This project contributes towards the following SDG(s):
- Uremic pruritus
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