This 3-year project continues our series researches on the nonlinear dynamics of dusty plasmas and complex systems. Nonlinear extended media driven by external persistent or stochastic drives can exhibits rich multiscale spatiotemporal dynamical behaviors. In the past three years, we conducted the following frontier researches: a) the micro-structure and dynamics of 2D liquids composed of dense rods with different aspect ratios, b) establishing 3D particle trajectory tracking technique for exploring micro-motion and structural rearrangement of 3D dusty plasma liquids, c) developing multidimensional empirical mode decomposition method to demonstrate that the 3D dust acoustic wave turbulence can be viewed as a zoo of multiscale interacting and entangling acoustic vortices with helical wave fronts winding around low amplitude filaments, d) demonstrating the rejuvenated dynamics of 2Dendothelial cells and turbulent like cancer cell motion, after the invasion of low fraction of more motile cancer into aged endothelial cells, through cancer cell aggregation, and e) identifying the precursor of Faraday rogue waves through the preceded surrounding waveform.In this new project, extending from our past researches, we will conduct the following researches: a) the transition to wave turbulence and how the nonlinear interaction and synchronization of different scale acoustic wave mode can lead to the formation of extremely low and high amplitude events, in the dust acoustic wave turbulence, b) the nonlinear mode-mode interaction between different phonon modes and the correlation with spatiotemporal evolution of different crystalline ordered domains in the 2D dusty plasma liquids and solid around freezing, c) the spatiotemporal evolution of micro-structure and motion in the quenched 3D dusty plasma liquid, d) the aggregation and motion of endothelia cells, cancer cells, and their mixtures under different concentration ratio and different motilities, and e) dynamics of wind driven water surface wave, and their transition to wave turbulence. f) nonlinear dynamics in other new systems. The above frontier studies, especially through the developed multi-dimensional empirical mode decomposition method, are important for understanding the generic behaviors of multi-scale excitations not only for dusty plasma systems, but also for other nonlinear extended complex systems.