For human physiology, the skeletal system plays an important role to support the whole-body shape and is composed of mineralized and fibrous connective tissues. Due to increase of elder age of worldwide population, bone disorders become crucial and significant public health concern. Tissue engineering is an interdisciplinary field that combines the principles of biomedical science and engineering with the goal of achieving human tissue regeneration or reconstruction. Few years ago, we have already demonstrated that human primary bone marrow-derived mesenchymal stem cells (bm-MSCs) could differentiated into mature bone-like tissues in the self-designed bioreactor system; however, it still existed some unsolved problems. Therefore, in this study, we propose some progressive strategies to ameliorate our previous design: (1) try to establish a complex structure like natural bone (bone-like organoids) through vasculogenesis and angiogenesis in the self-designed bioreactor system; (2) try to develop customized biodegradable bone-like graft using 3D-printing technology and integration of personalized bone-like organoids; (3) try to organize bioactive bone grafts (via VEGF immobilization) for facilitating clinical bone regeneration. We sincerely hope to provide a better overall solution for clinical bone regeneration.
|Effective start/end date
|1/08/21 → 31/10/22
UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This project contributes towards the following SDG(s):
- personalized bone-like organoids
- customized biomimetic bone grafts
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