研製開發促活體肝纖維化標靶奈米藥物載體之研究--材料合成及模型驗證

Project Details

Description

We aim to design and fabricate two kinds of nanoagents: (1) Keratin 8(KRT8)-targeting lipopolysaccharide-loaded Poly(D,L-lactide-co-glycolide) (PLGA)nanoparticles (TKLPNPs); (2) Transforming growth factor beta (TGF-beta)-targeting PLGA nanoparticles (TTPNPs), and explore their capabilities for establishment of a liver-fibrosis mouse model.
StatusActive
Effective start/end date1/01/2231/12/22

UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This project contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Keywords

  • Liver fibrosis
  • Animal model
  • Binding specificity
  • Nanoagent
  • Hepatocytes
  • hepatic stellate cells

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