研究瞳孔大小在視覺，知覺醒度，認知歷程的功能與調控：使用眼動與自律神經反應，大腦電刺激，計算與機器學習模型(3/5)

We move our eyes over 100,000 times each day. Saccades are rapid eye movements that bring the objects of interests to the fovea, enabling high-resolution visual images of relevant stimuli for subsequent information processing. Pupil size, determined mainly by the global luminance level, also changes constantly to optimize visual processing. Although the quality of the signal projected on the retina is already under the control of pupil size, how does pupil size modulate visual signals and visually-guided saccades remains poorly understood. Besides, developing an effective low-cost method for understanding human brain functions in health and disease is one of the most pressing challenges in psychology and neuroscience. Although eye movements have been greatly used to index cognitive and neural processing, the eye movement system includes saccades, pupil size, and microsaccades. Research that integrates these oculomotor responses is very limited. The goal of the project is to integrate saccades, pupil size, and microsaccades to understand the modulations of cognitive and emotional processes on these oculomotor responses. For example: how does the size of the pupil affect visual signals evoked by visual stimuli, and in turn modulates visually-guided saccades or microsaccades? Are similar neural mechanisms involved between cognition and arousal pupil size modulations? Through collaborating withlocal and international research teams, we aim to develop the computational model that integrates not only oculomotor but also autonomic and EEG responses in establishing behavioral biomarkers that facilitate the early diagnosis of diseases for effective therapeutic interventions.