生醫數據分析人才培育計畫–利用系統生物學運用人工智慧(AI)比較動態培養與動物實驗結果分析

Project Details

Description

Most of the current cell research still follows the two-dimensional static culture (1885~ ), which is very different from the "dynamic + three-dimensional" environment in vivo, resulting in obvious differences in cell morphology, differentiation, and cell-cell interactions from those in vivo. For further evidence, 3D culture technology has been applied in academic research, but there are still some problems to be solved in the current 3D culture, including most of the current 3D scaffolds that cannot analogize the biomechanical dynamic characteristics in vivo. However, animal experiments often have different results due to individual differences, lengthy time, huge funds, and differences between the training environment and the external environment faced by the real human body. The sacrifice of the lives of experimental animals also makes science extremely heavy.Cells in the body participate in their physiological pulsation all the time instead of being static in two dimensions. In the microenvironment of the human body, cells are not only faced with the impact of biochemical changes, but also many physical factors such as cell biomechanics are involved, including: Stretching, extrusion, shear force, softness and hardness of the matrix; mechanical and physical effects affect the human body at the microscopic level all the time. Every cell has mechanical receptors, receptors, and a cytoskeleton composed of specific proteins as a scaffold , large and small pillars and connecting rods, which in turn affect the functions of cell information transmission, survival, growth, differentiation and death.
StatusFinished
Effective start/end date1/01/2131/07/23

Keywords

  • system biology
  • artificial intelligence
  • dynamic culture

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