To push for low-energy consumption memory and logic spintronics devices, a reversal of magnetization requiring only the application of an electric field can be achieved via a ferroelectric (FE) barrier as an active role in magnetic tunnel junction. A number of model and first-principles calculation have focused on the tunneling magnetoresistance (TMR) and tunneling electroresistance (TER) effects for FM/FE/FM multiferroeic tunnel junctions (MFTJs) in collinear magnetic configuration. This gives rise to a four-state resistance device where resistance can be switched both by electric and magnetic fields. However, only few theoretical model but nearly no DFT calculation is applied for the non-collinear spin transport in MFTJs, due to the difficulties of the self-consistent calculation in non-collinear magnetic configurations. In this project, our newly developed “Junpy” program, combining the first-principles calculated Hamiltonian in collinear magnetic configuration with the non-equilibrium Green’s function (NEGF) method and the unitary transformation to investigate the spin torque effect for FM/BaTiO3/FM and FM/nucleobases in DNA/FM MFTJs in non-collinear magnetic configuration. We believe that these results may open a new avenue for next-generation, multifunctional and low-energy consumption spintronics devices.