Epigenetic assimilation in the aging human brain

  • Gabriel Oh (Creator)
  • Sasha Ebrahimi (Creator)
  • Sun-Chong Wang (Contributor)
  • Rene Cortese (Creator)
  • Zachary Kaminsky (Creator)
  • Irving I. Gottesman (Creator)
  • James R. Burke (Creator)
  • Brenda L. Plassman (Creator)
  • Arturas Petronis (Creator)
  • Art Petronis (Creator)



Abstract Background Epigenetic drift progressively increases variation in DNA modification profiles of aging cells, but the finale of such divergence remains elusive. In this study, we explored the dynamics of DNA modification and transcription in the later stages of human life. Results We find that brain tissues of older individuals (>75Â years) become more similar to each other, both epigenetically and transcriptionally, compared with younger individuals. Inter-individual epigenetic assimilation is concurrent with increasing similarity between the cerebral cortex and the cerebellum, which points to potential brain cell dedifferentiation. DNA modification analysis of twins affected with Alzheimerâ s disease reveals a potential for accelerated epigenetic assimilation in neurodegenerative disease. We also observe loss of boundaries and merging of neighboring DNA modification and transcriptomic domains over time. Conclusions Age-dependent epigenetic divergence, paradoxically, changes to convergence in the later stages of life. The newly described phenomena of epigenetic assimilation and tissue dedifferentiation may help us better understand the molecular mechanisms of aging and the origins of diseases for which age is a risk factor.
Date made available2016
  • Epigenetic assimilation in the aging human brain

    Oh, G., Ebrahimi, S., Wang, S. C., Cortese, R., Kaminsky, Z. A., Gottesman, I. I., Burke, J. R., Plassman, B. L. & Petronis, A., 28 Apr 2016, In: Genome Biology. 17, 1, 76.

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    Open Access
    37 Scopus citations

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